THURSDAY, April 1, 2021 (HealthDay Information) — Seizures and different epileptiform abnormalities are widespread in sufferers with COVID-19 present process clinically indicated steady electroencephalogram (cEEG) monitoring and are related to adversarial medical outcomes, in response to a examine printed on-line March 11 in Annals of Neurology.
Lu Lin, M.D., Ph.D., from the Beth Israel Deaconess Medical Middle in Boston, and colleagues assessed 197 sufferers with COVID-19 referred for cEEG at 9 taking part facilities to characterize the incidence of and medical danger components for seizures.
The researchers discovered that 9.6 % of sufferers had electrographic seizures, together with nonconvulsive standing epilepticus (NCSE) in 5.6 % of sufferers. Practically half (48.7 %) had epileptiform abnormalities (both ictal or interictal) current. There was an affiliation famous between medical seizures throughout hospitalization previous to initiation of EEG monitoring and each electrographic seizures (odds ratio, 6.51) and NCSE (odds ratio, 8.34). NCSE was additionally related to a preexisting intracranial lesion on neuroimaging (odds ratio, 4.33). Electrographic seizures have been discovered to be an unbiased predictor of in-hospital mortality (hazard ratio, 4.07).
“We discovered that seizures certainly can occur in sufferers with COVID-19 essential sickness, even these with none prior neurologic historical past, and that they’re related to worse outcomes: increased charges of loss of life and longer hospital keep, even after adjusting for different components,” a coauthor mentioned in a press release. “Our outcomes counsel that sufferers with COVID-19 must be monitored carefully for nonconvulsive seizures. Therapies can be found and warranted in sufferers at excessive danger; nonetheless, additional analysis is required to make clear how aggressively to deal with seizures in COVID-19.”